Applications
Accessibility
Firefox Accessibility Extension – Make Firefox more accessible
On-Screen Keyboard Portable – Easily access an on-screen keyboard
Virtual Magnifying Glass Portable – A full-featured screen magnifier
Development
Notepad++ Portable – A full-featured text editor with syntax highlighting
Nvu Portable & KompoZer Portable – The easy-to-use Nvu web editor
XAMPP – Apache, mySQL, PHP, phpMyAdmin, etc in one package
Games
DOSBox Portable – classic DOS games to go
Jooleem Portable – simple and addictive puzzle game with great music and visuals
Mines-Perfect Portable – a classic hunt-for-mines game with advanced features
PokerTH Portable – classic Texas Hold Em style poker at its best
Sudoku Portable – the wildly popular and addictive puzzle game
Graphics & Pictures
GIMP Portable – Photo and Image Editor
Internet
FileZilla Portable – the full-featured FTP client
FireFTP Extension (for Firefox) – a lightweight extension
Miranda IM Portable – chat with AOL, MSN and Yahoo users in a customizable interface
Mozilla Firefox, Portable Edition – the award-winning web browser that’s safe and secure
Mozilla Thunderbird, Portable Edition – the handy email client- Nvu Portable & KompoZer Portable – the easy-to-use webpage editor
Pidgin Portable – chat with AOL, MSN and Yahoo users in an easy-to-use interface
PuTTY Portable – lightweight telnet and SSH client
Sage Extension (for Firefox) – A full-featured RSS extension
WinSCP Portable – SFTP, FTP and SCP client
Music & Video
Audacity Portable – A simple audio editor and recorder
BonkEnc Portable – extract, convert, and encode audio
MPlayer Portable – Full-featured movie player with support for most video formats
VirtualDub Portable – video processing and capture utility
VLC Media Player Portable – An easy to use media player that plays most audio and video formats
Office
AbiWord Portable – a lightweight word processor compatible with Microsoft Word files
GnuCash Portable – accounting, expenses and financial management- Lightning Extension (for Thunderbird) – A lightweight extension for your calendar and tasks
Mozilla Sunbird, Portable Edition – Calendar and task management with a familiar interface- Mozilla Thunderbird, Portable Edition (Address Book) – Email client’s built-in address book with import/export functions
OpenOffice.org Portable – word processor, spreadsheet, presentations with Microsoft compatibility
PDFTK Builder Portable – split, collate, watermark and password protect PDF documents
Sumatra PDF Portable – a lightweight PDF viewer
Task Coach Portable – to do list and task manager
Operating Systems
Mac-on-Stick – Run Mac OS Classic 7 portably
Utilities
7-Zip Portable – File archiver and compressor
ClamWin Portable – Antivirus on the go
Command Prompt Portable – Simple link to a customizable command prompt
Eraser Portable – securely delete files and data
InfraRecorder Portable – full-featured CD and DVD burner
KeePass Password Safe Portable – Secure, easy-to-use password manager
PeaZip Portable – Easy to use file archiver and compressor
PortableApps.com Backup – integrated backup utility bundled with the platform- PortableApps.com Menu – integrated start menu bundled with the platform
Toucan – backup, sync and encrypt for advanced users
WinDirStat Portable – disk usage analyzer and cleanup tool
winMd5Sum Portable – check md5 sums to verify files on the go
WinMerge Portable – file comparison and merging
The Application Compatibility page gives a quick rundown of what applications work on what operating systems.